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OpenMRS is a collaborative open-source project to develop excellent software to support the delivery of health care in developing countries. It grew out of the critical need to scale up the treatment of HIV in Africa but from the start was conceived as a general-purpose electronic medical record system that could support the full range of medical treatments. The first ideas and prototype of OpenMRS were conceived by Paul Biondich and Burke Mamlin from the Regenstrief Institute, Indiana, on a visit to the AMPATH project in Eldoret, Kenya, in February 2004. Around the same time, the EMR team at Partners In Health, led by Hamish Fraser and Darius Jazayeri, were looking at ways to scale up the PIH-EMR web-based medical record system developed to manage drug-resistant tuberculosis in Peru and HIV in rural Haiti. Paul, Burke, and Hamish met in September 2004 at the Medinfo conference in San Francisco and recognized they had a common approach to medical information systems and a similar philosophy for healthcare and development, and OpenMRS was born. Later, Chris Seebregts of the South African Medical Research Council (MRC) became the fourth founding member.

OpenMRS is founded on the principles of openness and sharing of ideas, software, and strategies for deployment and use. The system is designed to be usable in very resource-poor environments and can be modified with the addition of new data items, forms, and reports without programming. It is intended as a platform that many organizations can adopt and modify, avoiding the need to develop a system from scratch.

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